Volume 1 Issue 3
Goat as Potential Animal Model for Transmissible Spongiform Encephalopathy using Spiroplasma mirum
Hilari M French*, DVM, PhD, Sue D Hagius, Charles M Boudreaux, Anthony T Bridges, Philip H Elzer, PhD
Spiroplasma mirum is the only species of Spiroplasma that has been found to be pathogenic to vertebrates. As the name describes, a strain from this species Suckling Mouse Cataract Agent (SMCA), when inoculated intracerebrally (IC), caused suckling mice to develop cataracts. The organism was able to persist in suckling mice, specifically the brain tissues, for up to two years. In 1979 Bastian reported spiral membranous inclusions seen by electron microscopy in brain biopsy tissues from a patient with Creutzfeldt-Jakob disease (CJD). Following this initial report of Spiroplasma-like inclusions in CJD tissues, Reyes published two case reports from patients with similar findings that were suspected of CJD.
Therapeutic Efficacy and Safety Evaluation of a Novel Chromium Supplement (Crominex®+3-) in Moderately Arthritic Horses
Kristi May, Ramesh C. Gupta*, Jean Miller, John T. Goad, Michelle A. Lasher, Roman Conway, Terry D. Canerdy, S. R. Kalidindi
Among all animal species, equine and canine suffer from arthritis more than any other species. Currently, millions of horses around the world suffer from osteoarthritis (OA). OA can inflict horses due to a single or multiple factors, such as aging, intense exercise, injury, immune disorder, genetic predisposition, and poor nutrition. OA, also known as chronic degenerative joint disease (DJD), is an inflammatory disease characterized by osteophyte formation, subchondral sclerosis and bone marrow lesions, and changes in the synovial membrane, progressive cartilage degeneration, and changes in the soft tissues of the joint.
Experimental Attempts To Induce Coccidiosis In Falcons
Faris Al-Timimi*, Dickson Kinyua, Peter Nolosco
Coccidia are very common intestinal protozoa infecting falcons in captivity. Apparently, more than one species have been detected in the fecal samples of falcons in the Gulf countries, without showing any signs of impaired or poor health. The incidence of coccidiosis is high and very common, and may exceed 60-70% of captive falcons. There is very little data available on the mode and origin of infection in falcons and therefore, they are not well understood compared to the mode and origin of infection in other domestic birds like pigeons, poultry and other cage and aviary birds.
Effectiveness and Safety of a Novel Flunixin Meglumine Transdermal Pour-On Solution in the Treatment of Bovine Respiratory Disease
Julien Thiry*, Juan Vicente González-Martín, Pascal Chenneveau, Bernard Van Huffel, Arwid Daugschies, Philippe Brianceau, Vincent de Haas
The safety and effectiveness of a new flunixin transdermal pour-on solution for cattle was evaluated as adjunct therapy in the treatment of bovine respiratory disease (BRD), compared to a positive control group treated with carprofen injectable solution. A total of 206 animals, showing severe signs of respiratory disease, were randomly assigned to treatment with either the test product, flunixin (Finadyne® Transdermal; MSD Animal Health) administered topically once along the dorsal midline, or the control product, carprofen (Rimadyl®; Zoetis) administered by subcutaneous injection once, on day 0.